Fig. 5: Safety and tolerability evaluation of an anti-Meflin ADC in mice. | Oncogene

Fig. 5: Safety and tolerability evaluation of an anti-Meflin ADC in mice.

From: Meflin is a druggable target using antibody-drug conjugates in progressive osteosarcoma

Fig. 5: Safety and tolerability evaluation of an anti-Meflin ADC in mice.

A The internalization of an anti-mouse Meflin monoclonal antibody (clone 21-3) was analyzed by an internalization assay using CHO Flp-In cells (left panel) and CHO Flp-In cells stably expressing mouse Meflin (mMeflin) (right panel). Arrowheads denote cells with antibody internalization. B–D 21-3 ADC was i.v. administered to 8-week-old male C57BL/6 mice (N = 3) at the indicated doses four times every seven days. Body weight was measured over time B, followed by sacrifice on Day 28 for the assessment of hematological values C, blood biochemistry. *, P < 0.05.

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