Fig. 1: RNF187 expression is elevated in pancreatic cancer and correlates with NEDD8. | Oncogene

Fig. 1: RNF187 expression is elevated in pancreatic cancer and correlates with NEDD8.

From: RNF187 neddylation in pancreatic cancer activates malignancy via IQGAP1-dependent actin cytoskeleton rearrangement

Fig. 1: RNF187 expression is elevated in pancreatic cancer and correlates with NEDD8.The alternative text for this image may have been generated using AI.

A Venn diagram identifying NEDD8-associated genes and overlapping E3 ligase genes. B Correlation analysis between RNF187 and NEDD8 expression. C RNF187 expression levels in PC (n = 179) and normal tissues (n = 171) from the GEPIA database. D Uniform Manifold Approximation and Projection (UMAP) plot illustrating distinct cell types. E Single-cell RNA sequencing analysis comparing RNF187 expression in cancer cells versus ductal cells. F qRT-PCR analysis of RNF187 mRNA expression in PC cells and HPDE cells. G Western blot analysis of RNF187 protein expression in PC cells and HPDE cells. H Kaplan–Meier survival curves depicting disease-free survival (DFS) based on RNF187 expression in PC patients. I IHC analysis of RNF187 expression in PC tissues from the Human Protein Atlas (HPA). J–L RNF187 mRNA and protein expression levels in PC patients, comparing tumor (T) and adjacent normal (N) tissues (Normal = 23, Tumor = 38). (M) IHC staining of RNF187 in PC and surrounding normal tissues (N = 17). All data are expressed as the mean ± SD (three independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001.

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