Fig. 5: Elevated SLC25A15 in mut-ER cells promotes BC cell adaptation to the liver microenvironment. | Oncogene

Fig. 5: Elevated SLC25A15 in mut-ER cells promotes BC cell adaptation to the liver microenvironment.

From: The role of the SLC25A15 transporter in the formation of liver metastasis in ESR1-mutated breast cancer

Fig. 5

A scheme representing the adaptation mechanism of mut-ER cells in the liver environment. The liver is enriched with ammonia (1), which mutated cells adapt to utilize due to higher expression of SLC25A15 (2), thereby enabling a higher UC rate (3). This allows cells to generate essential building blocks such as orotate, which is involved in the synthesis of nucleotides and polyamines.

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