Fig. 1: Elevated levels of MICAL2 in NPC alleviate ferroptosis-induced oxidative damage. | Oncogene

Fig. 1: Elevated levels of MICAL2 in NPC alleviate ferroptosis-induced oxidative damage.

From: LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma

Fig. 1: Elevated levels of MICAL2 in NPC alleviate ferroptosis-induced oxidative damage.The alternative text for this image may have been generated using AI.

A MICAL2 staining images of NPC tissue microarray in different clinical stages (scale bar: 200 μm) and the staining scores (one-way ANOVA). B–E The relationship between MICAL2 expression and lymph node metastasis, recurrence, and metastasis in NPC patients (n = 132). F The Kaplan–Meier curves show the Overall Survival, Progression-Free Survival and Disease-Free Survival (log-rank test). G WB measured the expression of PTGS2, GPX4, FTH1 protein. H Fixable Viability Dye staining assays using sh-Ctrl or sh-MICAL2 CNE1 and CNE2 cells treated with relative inhibitors. I Flow cytometry analysis used to detect ROS content. J)Ferro-Orange probes used to detect Fe2+ content. K the ratio of intracellular GSH/GSSG content was measured in shMICAL2 cells. Data sets the mean ± SD of at least three independent experiments: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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