Fig. 2: Inhibition of PIAS4 blocks cell cycle G1 phase progression and inhibits cell proliferation. | Oncogene

Fig. 2: Inhibition of PIAS4 blocks cell cycle G1 phase progression and inhibits cell proliferation.

From: PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment

Fig. 2: Inhibition of PIAS4 blocks cell cycle G1 phase progression and inhibits cell proliferation.

A Biological processes associated with PIAS4 were elucidated using the enrichment tool DAVID. B Enrichment analysis revealed PIAS4-targeted genes in the KEGG pathway via GSEA. C Enrichment analysis revealed PIAS4-knockdowned genes in the cell cycle via GSEA. D–F Interference of PIAS4 in PIAS4 + / + MEF (D), MCF7 (E), and BT-474 (F) cells was assessed using MTS assay to determine relative cell viability.

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