Fig. 3: Knocking down the YTHDF3 expression inhibits bone metastasis, lung metastasis, and osteolytic bone destruction of breast cancer cell lines in vivo. | Oncogenesis

Fig. 3: Knocking down the YTHDF3 expression inhibits bone metastasis, lung metastasis, and osteolytic bone destruction of breast cancer cell lines in vivo.

From: YTHDF3 promotes breast cancer osteolytic bone metastasis by enhancing the translation of ZEB1 and SMAD5

Fig. 3

A Living imaging results 0 week and 4weeks after injection of 231-BO-shNC-luc (n = 6) and 231-BO-shYTHDF3-1-luc (n = 6) cells via left ventricle. Tumor fluorescence signal was also quantified. B Living imaging photos 4 weeks after infection of 231-HM-shNC-luc (n = 5) and 231-HM-shYTHDF3-luc (n = 5) cells injection via tail vein and tumor fluorescence was quantified. C Representative H&E and CK18 IHC images of mice lung metastasis lesion showed different tumor burden between two groups. D Living imaging photos 4 weeks after infection of 231-BO-shNC-luc (n = 6) and 231-BO-shYTHDF3-1-luc (n = 6) cells into the tibial plateau and the bone lesion flux was indicated by fluorescence signals.

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