Fig. 7: Mechanism plot. | Oncogenesis

Fig. 7: Mechanism plot.

From: YTHDF3 promotes breast cancer osteolytic bone metastasis by enhancing the translation of ZEB1 and SMAD5

Fig. 7

Overexpression of YTHDF3 in breast cancer cells upregulates the expression of ZEB1 and SMAD5 by reading and recognizing m6A modified sequences in mRNAs. The increasing level of ZEB1 and SMAD5 promotes the EMT process so that increasing the invasiveness of breast cancer cells. Furthermore, in bone microenvironment, ZEB1 boosts the expression of WNT5B, thus increasing the osteoclast differentiation and finally causing osteolytic lesions.

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