Fig. 1: Single-cell transcriptomic analysis reveals Rab37-dependent regulation of macrophage phenotype and intercellular communication in the lung TME. | Oncogenesis

Fig. 1: Single-cell transcriptomic analysis reveals Rab37-dependent regulation of macrophage phenotype and intercellular communication in the lung TME.

From: Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression

Fig. 1

A Schematic workflow of the experimental design. CD45+ immune cells were isolated from lung tissues of Rab37 WT and KO C57BL/6 mice injected with Matrigel (control) or tumor cells (LLC tumor-bearing), followed by scRNA-seq using the 10× Genomics platform. B UMAP plot showing clustering of immune cells into major populations. C Stacked bar plots illustrating the distribution of immune cell subsets across experimental groups. D Dot plot showing the expression of representative anti-inflammatory and pro-inflammatory markers in macrophages. CellChat chord diagrams depicting macrophage outgoing signaling interactions with other immune subsets in Rab37 WT (E) and KO (F) lung TME.

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