Fig. 5: Schematic illustration of Rab37-mediated regulation of OPN secretion and its functional consequences in the lung TME. | Oncogenesis

Fig. 5: Schematic illustration of Rab37-mediated regulation of OPN secretion and its functional consequences in the lung TME.

From: Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression

Fig. 5

Diagram showing Rab37-dependent vesicle trafficking of OPN in macrophages, followed by its secretion into the extracellular space. Secreted OPN activates the JAK2–STAT3 pathway in macrophages to enhance Spp1 transcription, establishing an autocrine positive feedback loop. In parallel, OPN acts in a paracrine manner to promote M2 macrophage polarization and to drive lung cancer cell proliferation and migration.

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