Fig. 1: ZBTB7B expression is elevated in LUAD and is associated with unfavorable prognosis and tumorigenesis. | Oncogenesis

Fig. 1: ZBTB7B expression is elevated in LUAD and is associated with unfavorable prognosis and tumorigenesis.

From: Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma

Fig. 1: ZBTB7B expression is elevated in LUAD and is associated with unfavorable prognosis and tumorigenesis.

A Box plot illustrating ZBTB7B expression levels in normal lung tissues (n = 111) and LUAD tissues (n = 111) using CPTAC datasets. B Western blot analysis of ZBTB7B protein levels in paired LUAD tumor tissues (T) and adjacent normal tissues (N) from 12 patients. C Quantification of ZBTB7B protein levels from Western blots in (B). D Western blot was conducted to assess ZBTB7B expression in the human bronchial epithelial cell line (BEAS-2B) and various LUAD cell lines (SPC-A1, PC9, H292, H1975, A549, and H1299). The right panel shows densitometric quantification relative to BEAS-2B. E Representative immunohistochemical staining of ZBTB7B in LUAD microarray. Scale bar = 400 μm. F Quantitative analysis of immunohistochemistry staining scores in LUAD microarray. G Kaplan–Meier survival analysis illustrating overall survival of LUAD patients stratified by ZBTB7B expression. (H-J) Correlation of EGFR, MET, BRAF and ZBTB7B expression in CPTAC database. Data are presented as mean ± SD of at least three independent experiments. **p < 0.01, ***p < 0.001.

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