Fig. 5: Changes in the microstructure of white matter tracts in children at school age who received therapeutic hypothermia for hypoxic-ischemic encephalopathy in infancy.
From: Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art
Decreased Fractional anisotropy in regions of corpus callosum in children cooled for HIE (cases) compared to controls (a), areas of increased RD in case children (b) and areas in which males exhibit larger case-control differences in RD than females (c). Results of voxel-wise comparison of FA on the white matter skeleton (green) showing widespread reduction in FA in children cooled for HIE and did not have CP compared with control children after adjusting for age and sex (d). The color bar shows significant differences (p < 0.05, Threshold free cluster enhancement corrected. These are overlaid on the MNI standard template. Labels indicate some major white matter tracts and regions. Abbreviations are as follows: anterior thalamic radiation (ATR), corpus callosum (CC), external capsule (EC), internal capsule (IC), inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), uncinate fasciculus (UF). Differences are most notable in the IC, CC, fornix, and cingulum. Adapted from.69,70 Creative Commons Attribution License.
