Table 2 Time from birth to weight regain (time-to-regain) categories and association with in-hospital outcomes.

From: Time to regain birthweight and in-hospital outcomes among United States-born extremely preterm newborns

Event

Odds Ratio (95%CI)

p-value

Adjusted Odds Ratio (95%CI)

Adjusted p-value

Linear Trend: Adjusted Odds Ratio (95%CI)

p-value

Death before discharge (N = 876)

 Regain day ≤5

1.66 (0.62, 4.46)

0.31

0.60 (0.17, 2.15)

0.43

1.12 (0.78, 1.62)

0.54

 Regain day 6–8

1.79 (0.69, 4.64)

0.23

1.26 (0.47, 3.37)

0.65

 Regain day 9–11

0.98 (0.32, 2.97)

0.97

0.85 (0.27, 2.71)

0.78

 Regain day ≥12

Reference

—

Reference

-

NEC (N = 858)

 Regain day ≤5

1.07 (0.52, 2.21)

0.85

0.51 (0.22, 1.19)

0.12

1.25 (0.97, 1.60)

0.09

 Regain day 6–8

1.02 (0.51, 2.08)

0.95

0.85 (0.41, 1.80)

0.68

 Regain day 9–11

1.28 (0.65, 2.51)

0.48

1.17 (0.58, 32.38)

0.66

 Regain day ≥12

Reference

—

Reference

-

BPD (N = 847)

 Regain day ≤5

1.74 (1.14, 2.66)

0.01

1.25 (0.74, 2.12)

0.40

0.91 (0.77, 1.07)

0.26

 Regain day 6–8

1.23 (0.83, 1.83)

0.31

1.33 (0.85, 2.09)

0.22

 Regain day 9–11

1.11 (0.75, 1.65)

0.61

1.06 (0.69, 1.63)

0.79

 Regain day ≥12

Reference

—

Reference

-

ROP (N = 847)

 Regain day ≤5

1.81 (0.97, 3.83)

0.06

0.69 (0.28, 1.66)

0.41

1.17 (0.86, 1.59)

0.33

 Regain day 6–8

0.57 (0.26, 1.22)

0.15

0.38 (0.17, 0.85)

0.02

 Regain day 9–11

0.83 (0.40, 1.70)

0.61

0.65 (0.31, 1.37)

0.25

 Regain day ≥12

Reference

—

Reference

-

Event

Estimate (95% CI)

p-value

Adjusted Estimate (95% CI)

p-value

Linear Trend: Adjusted Estimate (95%CI)

p-value

Length of stay (days) (N = 828)

 Regain day ≤5

8.82 (−1.17, 18.8)

0.08

−4.99 (−15.7, 5.67)

0.35

1.35 (−1.81, 4.50)

0.40

 Regain day 6–8

10.10 (−0.91, 21.1)

0.07

6.06 (−4.80, 16.9)

0.27

 Regain day 9–11

3.01 (−5.47, 11.5)

0.49

−1.75 (−10.6, 7.14)

0.70

 Regain day ≥12

Reference

—

Reference

-

  1. Generalized estimating equations (GEE) used with robust standard errors to account for clustering for multiple gestation deliveries. Adjusted regression models included GA, treatment group, mode of delivery, vasopressor use in the first 14 days (including dopamine, norepinephrine, epinephrine, dobutamine, vasopressin, or milrinone), postnatal steroid use in the first 14 days (hydrocortisone or dexamethasone), birthweight z-score, mechanical ventilation at baseline, and quartile of average total fluids in the first 14 days after birth. Only neonates surviving at least 14 days included in mortality, NEC, and length of stay analyses. Neonates surviving to 36 weeks corrected gestational age included in BPD and ROP analyses. Logistic regression models were used for binary outcomes and linear regression model were used for length of stay. Significant p-values bolded.
  2. NEC Necrotizing enterocolitis, BPD Bronchopulmonary dysplasia, ROP Retinopathy of Prematurity.
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