Table 3 Descriptive characteristics of the distribution of DBGM summative C-Scores across 8155 genes by all study participants, the discordant sibling subgroup and the unrelated participant subgroup

From: Variant burden and severity of cardiomyopathy in patients with DMD-related Duchenne muscular dystrophy

 

All Study Participants

Discordant Sibling Cohort

Unrelated Participants Cohort

n

54

13

23

Range for DBGM summative C-Scores

−7.503224 to 7.24595

−16.3946 to 9.037867

−5.103426 to 14.60235

Mean DBGM summative C-Scores (SD)

0.0070217 (0.4143616)

−0.003941 (0.616156)

0.0084 (0.6299962)

Median DBGM summative C-Scores (IQR)

−0.0522233 (0.3373394)

0 (0.0629071)

0 (0.00547094)

Mean DBGM summative C-Scores 3 Standard Deviation Cut Offs

−1.2360631, 1.2501065

−1.852409, 1.844527

−1.8815886, 1.8983886

Number of Genes with DBGM summative C-Score more than 3 Standard Deviations from the Mean

159

134

136

  1. DBGM difference between group mean.