Fig. 8: Trial sequential analysis of Buccal Midazolam and Rectal Diazepam Therapeutic effect. | Pediatric Research

Fig. 8: Trial sequential analysis of Buccal Midazolam and Rectal Diazepam Therapeutic effect.

From: Efficacy, safety, route of administration of midazolam and diazepam for pediatric status epilepticus: systematic review, meta-analysis, and trial sequential analysis

Fig. 8: Trial sequential analysis of Buccal Midazolam and Rectal Diazepam Therapeutic effect.

Trial sequential analysis of the therapeutic success of Buccal Midazolam versus Rectal Diazepam was conducted using a Random-effects model (DL). The conventional meta-analysis for this comparison showed a significant pooled effect (RR = 1.32, 95% CI: 1.09 to 1.59; P value: 0.005), with observed heterogeneity (I2 = 0.63, Q = 5.43, P value: 0.0662) and diversity (D2 = 0.72). The TSA was based on a double-sided alpha of 0.05 and a beta of 0.20 (power of 80%). The cumulative Z-curve (blue line) crossed both the conventional statistical significance boundary and superiority boundary. With a Required Information Size (RIS) of 559 patients, the cumulative evidence is considered conclusive and statistically sufficient to demonstrate no need for further trials.

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