Table 1 Association of BRCA1/2 germline mutations with race and tumor characteristics (combined three cohorts, N = 1240)

From: Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population

Variable

WT/benign/likely benigna

VUSb

Pathogenicc

P value

Race

 AA

412 (94.1)

20 (4.6)

6 (1.4)

0.0063

 CA

750 (97.4)

12 (1.6)

8 (1.0)

Clinical stage

 Early stage (T2)

984 (96.5)

29 (2.8)

7 (0.7)

0.0206

 Advanced stage (T3–4/N1/M1/D3)

182 (94.3)

5 (2.6)

6 (3.1)

Biopsy Gleason sum

 6 or less

659 (96.6)

19 (2.8)

4 (0.6)

0.0331

 7

317 (95.5)

11 (3.3)

4 (1.2)

 8–10

169 (95.5)

2 (1.1)

6 (3.4)

  1. Numbers in parenthesis indicate % values
  2. aWild type BRCA1/2 and benign/likely benign mutations in BRCA1/2
  3. bVariants of unknown significance in BRCA1/2
  4. cPathogenic mutations in BRCA1/2
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