Table 2 Firth’s penalized logistic regression for Decipher and CAPRA for AP in F-IR cohort (n = 220)

From: Decipher identifies men with otherwise clinically favorable-intermediate risk disease who may not be good candidates for active surveillance

Model

Variable

Odds ratio (95% CI)

p value

AUC (95% CI)

Univariable

CAPRA

1.64 (1.03−2.68)

0.038*

0.60 (0.51−0.70)

Decipher

1.34 (1.11−1.63)

0.002*

0.63 (0.52−0.74)

Decipher int vs. low

0.85 (0.22−2.54)

0.789

—

Decipher high vs. low

4.60 (1.59−12.90)

0.006*

—

CAPRA + Decipher

CAPRA

1.46 (0.91−2.39)

0.117

0.65 (0.57−0.71)a

Decipher

1.31 (1.08−1.60)

0.006*

 

CAPRA + Decipher (risk group)

CAPRA

1.78 (1.10−2.97)

0.018*

—

Decipher int vs. low

0.61 (0.15−1.91)

0.422

 

Decipher high vs. low

4.92 (1.65−14.41)

0.005*

 
  1. Odds ratios of Decipher were reported per 0.1 unit increased
  2. CAPRA Cancer of the Prostate Risk Assessment, AP adverse pathology, F-IR NCCN favorable-intermediate risk
  3. aAUC was adjusted for optimism
  4. *p value < 0.05
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