Fig. 1: The course of prostate cancer.

Reproduced with permission from Anantharaman A, Small EJ. Tackling nonmetastatic castration-resistant prostate cancer: special considerations in treatment. Expert Rev Anticancer Ther. 2017. ADT androgen-deprivation therapy, CRPC castration-resistant prostate cancer, HSPC hormone-sensitive prostate cancer, M0 nonmetastatic, Met metastatic, PSA prostate-specific antigen.