Table 1 Population characteristics, the cohort of prostate cancer patients treated with androgen deprivation therapy.
Participants starting ADT | ||
|---|---|---|
Statin use during the follow-up (1996–2015) | ||
None | Any | |
No of men | 1884 | 2544 |
No of PCa deaths | 482 (25.6%) | 352 (13.8%) |
No of overall deaths | 1009 (53.6%) | 918 (36.1%) |
Median (IQR) follow-up time (years) after ADT initiation | 5.5 (2.6–9.4) | 6.9 (3.6–10.6) |
Mean age at PCa diagnosis (years) | 69.0 | 69.7 |
Mean age at ADT initiation | 70.1 | 70.9 |
BMI; median (IQR) | 26.0 (23.7–28.7) | 26.8 (24.7–29.1) |
Tumor stage at diagnosis | ||
T1–2 | 1 146 (60.8%) | 1 781 (70.0%) |
T3–4 | 737 (39.2%) | 763 (30.0%) |
Unknown | 1 (0.02%) | 0 |
Tumor Gleason grade | ||
6 or lower | 583 (30.9%) | 886 (34.8%) |
7 | 671 (35.6%) | 957 (37.6%) |
8–10 | 575 (30.5%) | 660 (25.9%) |
Metastatic disease at diagnosis (M1) | 316 (16.8%) | 240 (9.4%) |
PSA level at diagnosis | ||
20 or less | 1 076 (57.1%) | 1 665 (65.4%) |
Above 20 | 645 (34.2%) | 640 (25.2%) |
Unknown | 163 (8.7%) | 239 (9.4%) |
Choice of primary treatment | ||
Active surveillance | 142 (7.5%) | 248 (9.7%) |
Radical prostatectomy | 148 (7.9%) | 184 (7.2%) |
Radical radiotherapy | 205 (10.9%) | 333 (13.1%) |
LHRH | 986 (52.3%) | 1434 (56.4%) |
Other | 403 (21.4%) | 345 (13.6%) |
PSA relapse | 723 (38.4%) | 842 (33.1%) |
EAU risk group | ||
Low-risk | 288 (15.3%) | 480 (18.9%) |
Intermediate-risk | 625 (33.2%) | 1014 (39.9%) |
High-risk | 971 (51.5%) | 1050 (41.3%) |
Use of other medication | ||
Andiabetic drugs | 220 (11.7%) | 745 (29.3%) |
Antihypertensive drugs | 1 152 (61.1%) | 2 173 (85.4%) |
NSAIDs | 1 545 (82.0%) | 2 218 (87.2%) |
Aspirin | 133 (7.1%) | 448 (17.6%) |
Type of ADT (categories not mutually exclusive) | ||
GnRH agonist/antagonist | 1 497 (79.5%) | 2 096 (82.4%) |
Antiandrogens | 1 116 (59.2%) | 1 390 (54.6%) |
Orchiectomy | 210 (11.1%) | 184 (7.2%) |
Radiation therapy | ||
None | 1 009 (53.6%) | 1 111 (43.7%) |
Yes | 875 (46.4%) | 1 433 (56.3%) |
Socioeconomic status | ||
Employed | 234 (12.4%) | 269 (10.6%) |
Unemployed | 64 (3.4%) | 47 (1.8%) |
Retired | 1 562 (82.9%) | 2 210 (86.9%) |
Unknown | 24 (1.3%) | 18 (0.7%) |
Marital status | ||
Single/divorced/widow | 626 (33.2%) | 618 (24.3%) |
Married/registered partnership | 1 258 (66.8%) | 1 926 (75.7%) |
