Fig. 5: Upstream regulators of KLK3 and ACP3 genes expression.
From: Prostate epithelial genes define therapy-relevant prostate cancer molecular subtype
KLK3 (a) and ACP3 (b) genes promoters and enhancers public ChIP-seq data integrative analysis (original data available from the Signaling Pathways. Each transcriptional factor binding site was identified by the Model-based Analysis of ChIP-seq (MACS2) algorithm and ranked by the MACS2 score. Top 10 TFs are listed. c a schematic diagram of transcriptional regulators of KLK3 and ACP3 genes. Note that while both genes are regulated by AR and AR cofactors, ACP3 is (in addition) regulated by pro-inflammatory factors such as STAT1/3 and IRF1.
