Table 1 Descriptive characteristics of the patient population.
Overall, n = 1293 | ISUP2 on final pathology, n = 1260 | Downgrading to ISUP1, n = 33 | p value | |
|---|---|---|---|---|
Age at Dx, years | 65 (60, 70) | 65 (60, 70) | 67 (60, 70) | 0.9 |
PSA at diagnosis, ng/ml | 6.8 (5.0, 9.6) | 6.8 (5.0, 9.6) | 7.0 (5.1, 8.8) | 0.8 |
Biopsy status, n (%) | ||||
No prior biopsy | 983 (76%) | 957 (76%) | 26 (79%) | 0.9 |
1 | 145 (11%) | 142 (11%) | 3 (9%) | |
2 | 165 (13%) | 161 (13%) | 4 (12%) | |
Biopsy route, n (%) | ||||
Trans-rectal | 867 (67%) | 839 (67%) | 28 (85%) | 0.03 |
Trans-perineal | 426 (33%) | 421 (33%) | 5 (15%) | |
Prostate volume on mpMRI, ml | 41.0 (30.0, 56.5) | 41.0 (30.0, 56.0) | 40.2 (35.0, 76.5) | 0.11 |
Number of lesions, n (%) | ||||
1 | 849 (66%) | 829 (66%) | 20 (61%) | 0.8 |
2 | 324 (25%) | 314 (25%) | 10 (30%) | |
≥3 | 120 (9%) | 117 (9%) | 3 (9%) | |
Max diameter index lesion, n (%) | 10 (8, 15) | 10 (8, 14) | 13 (9, 15) | 0.4 |
Total number of biopsy cores, n (%) | 14 (12, 16) | 14 (12, 16) | 14 (13, 15) | 0.9 |
Total number of positive biopsy cores, n (%) | 5 (3, 7) | 5 (3, 7) | 3 (2, 5) | 0.009 |
Total cancer core length, mm | 21 (11, 36) | 22 (11, 36) | 11 (4, 22) | <0.001 |
Max cancer core length, mm | 8 (5, 12) | 8 (5, 12) | 5 (3, 7) | <0.001 |
Max % core involvement, mm | 43 (28, 64) | 44 (28, 65) | 36 (25, 56) | 0.2 |
GG on systematic biopsy, n (%) | ||||
0 | 228 (18%) | 223 (18%) | 5 (15%) | 0.03 |
1 | 215 (17%) | 204 (16%) | 11 (33%) | |
2 | 850 (66%) | 833 (66%) | 17 (52%) | |
pT stage | ||||
2 | 782 (60%) | 753 (60%) | 29 (88%) | 0.01 |
3a | 417 (32%) | 413 (33%) | 4 (12%) | |
3b | 82 (6%) | 82 (7%) | 0 (0%) | |
4 | 12 (1%) | 12 (1%) | 0 (0%) | |
Pathologic ISUP | ||||
1 | 33 (3%) | 0 (0%) | 33 (100%) | <0.001 |
2 | 933 (72%) | 933 (74%) | 0 (0%) | |
3 | 291 (23%) | 291 (23%) | 0 (0%) | |
4 | 19 (1%) | 19 (2%) | 0 (0%) | |
5 | 17 (1%) | 17 (1%) | 0 (0%) | |
Lymph node invasion | ||||
Absent | 1256 (97%) | 1223 (97%) | 33 (100%) | 0.3 |
Present | 37 (3%) | 37 (3%) | 0 (0%) | |
