Table 2 Potential reasons for false-positive and false-negative findings with PSMA PET [52, 81, 82].

From: Application of next-generation imaging in biochemically recurrent prostate cancer

False-positive findings

False-negative findings

Low SUVmaxa

Adjacent bladder activity

Non-specific ligand uptake

Lack of or low PSMA expression

Post EBRT residual activity

Small metastases

Inflammation

  1. EBRT external beam radiation therapy, max maximum, PET positron emission tomography, PSMA prostate-specific membrane antigen, SUV standardized uptake values.
  2. aThreshold not clearly defined.
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