Fig. 3
From: Cancer cachexia: molecular basis and therapeutic advances
Overview of the interactions between systemic metabolic remodeling and the cellular inflammatory response in cancer cachexia. Crosstalk among various tissues and organs contributes to the complex clinical manifestations observed in cancer cachexia, which is characterized by metabolic disturbances. Systemic metabolic remodeling is potentially associated with the cellular inflammatory response. Subsequently, the cells that undergo functional and quantitative alterations, along with the cachexia-associated factors they secrete, penetrate the vascular system and influence remote target organs/tissues. These inflammatory alterations can lead to a shift toward a catabolic state in terms of systemic metabolism, thereby exacerbating the progression of cancer cachexia. The network diagram above illustrates the intricate interplay between organs and tissues. The left chart below depicts the metabolic reprogramming that occurs in the state of cachexia, whereas the right chart below reveals the specific impacts of these metabolites on various cell types, which in turn affect target organs, further exacerbating the systemic metabolic imbalance. This figure was created with BioRender (https://biorender.com)
