Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination

Fig. 5

In vivo effects of Cu–DHN (Cu:DHN:Cys = 0.6:1:0.2) on 4T1 tumor. a Schematic illustration of inhibiting tumor growth via inducing pyroptosis, cuproptosis, and ferroptosis by a single intratumoral injection of Cu–DHN. b Longitudinal monitoring of tumor growth following single-dose Cu–DHN intratumoral administration (3.78 μmol kg−1 Cu, 6.24 μmol kg−1 DHN or juglone) (n = 5). c Weights of dissected tumors, and d tumor inhibition rate at 14 days post-treatment (n = 5). e Survival rate analysis of 4T1 tumor-bearing BALB/c mice treated with Cu–DHN (n = 8). f CLSM images and MFI of tumor slices labeled with g DHE (1 day post-treatment), h GSDMD-N antibody (14 days post-treatment), i FDX1 antibody (14 days post-treatment), j Liperfluo (1 day post-treatment), and H&E (14 days post-treatment) (n = 3). Data are represented as mean ± SD

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