Table 1 LSD1 inhibition activity of compounds 1–9

From: Potent and selective LSD1 inhibitor DC551040 reveals a promising combination therapy for AML with insight into epigenetic dysregulation

Compd.

R

LSD1

IC50 (nM)a

1

Me

53.67 ± 1.24

2

41.05 ± 3.17

3

67.81 ± 6.05

4

47.22 ± 5.19

5

62.98 ± 5.63

6

COMe

319.30 ± 25.67

7

41.85 ± 2.92

8

21.42 ± 1.19

9

33.07 ± 6.43

(1R,2S)-8 (DC551040)

2.14 ± 0.61

(1S,2R)-8

58.39 ± 4.24

GSK2879552

139.46 ± 44.09

  1. Data represent mean values ± SEM
  2. aSee Experimental Section
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