Fig. 3
Correlation between coagulation or blood-lipid measurements and cardiac function indicators. a Summary of anticoagulant use in each group (1 = users; 0 = non-users); P values were calculated using the chi-square test. b D-dimer levels stratified by anticoagulant status; P values were obtained using Spearman correlation. Red P values indicate P < α (0.05). c, d Pearson correlation coefficients (r) between baseline-relative fractional changes (BRF; averaged over V9-V10) in coagulation/blood-lipid metrics and cardiac function measures (averaged over V11-V12), displayed as heat maps (positive correlations in coral orange; negative correlations in mint green; color intensity reflects |r | ); significant correlations (P < 0.05) are marked with an asterisk. e, f Pearson and Mantel correlation analyses between the unadjusted Heart Function Index (HFI; composite of LVEF, LVFS, LVESV, LVEDV, FAC, RVESV, RVEDV, TAPSE, NT-proBNP, and ST2) at baseline (V0), Day 180 (V11), and Day 360 (V12), and coagulation or lipid metrics. Pearson correlations are shown as heat maps (positive in pink; negative in light blue; color intensity reflects |r | ). Mantel coefficients are represented by line thickness, and Mantel P values by line color (gray, P > 0.05; red, 0.01 < P ≤ 0.05; deep red, 0.001 < P ≤ 0.01). BRF baseline-relative fractional change, defined as (Xt − X0) / X0, where X0 is the baseline value at V0 and Xt is the mean of V9 and V10
