Fig. 3: Surgical castration alters gene expression in dorsal Hippocampus (dHipp). | Translational Psychiatry

Fig. 3: Surgical castration alters gene expression in dorsal Hippocampus (dHipp).

From: Effects of vortioxetine on hippocampal-related cognitive impairment induced in rats by androgen deprivation as a model of prostate cancer treatment

Fig. 3

Volcano plots depict differential gene expression in dHipp after castration and vortioxetine treatment. Dashed lines represent significance criteria: |FC| ≥ 2 and p < 0.01. Genes downregulated are denoted in blue and genes in red were upregulated. A In the main effect of castration, there were 279 genes that were differentially affected (165 were upregulated and 114 were downregulated). B In the main effect of vortioxetine treatment, 4 genes were downregulated and 7 genes upregulated. C Within the interaction of castration x vortioxetine, there were seven genes upregulated and 6 genes downregulated.

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