Fig. 4: Hallmark and KEGG pathways from Gene Set Enrichment Analysis (GSEA) of genes affected by androgen deprivation and vortioxetine. | Translational Psychiatry

Fig. 4: Hallmark and KEGG pathways from Gene Set Enrichment Analysis (GSEA) of genes affected by androgen deprivation and vortioxetine.

From: Effects of vortioxetine on hippocampal-related cognitive impairment induced in rats by androgen deprivation as a model of prostate cancer treatment

Fig. 4

Pathways were identified by q value < 0.05 and ordered by normalized enrichment score. Hallmark pathways were identified in A the main effect of castration (castration-control vs. intact-control), B the main effect of vortioxetine (intact-vortioxetine vs. intact-control), and C the interaction of vortioxetine x castration (castration-vortioxetine vs. castration-control). KEGG pathways were identified in D the main effect of castration and E the main effect of vortioxetine. Pathways in the interaction did not meet the threshold for significance of q < 0.05.

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