Table 1 Effects of androgen deprivation on gene expression in dorsal hippocampus.

From: Effects of vortioxetine on hippocampal-related cognitive impairment induced in rats by androgen deprivation as a model of prostate cancer treatment

Gene name/ID	Log2(FC)	P value	Gene name/ID	Log2(FC)	P value	Gene name/ID	Log2(FC)	P value
Main effect of castration (castrated/control—intact/control)
DCP_1_0	−3.359	0.000000054	Glrb *	−1.332	0.000019457	Tvp23b	−1.143	0.000029548
(+)E1A_r60_1	−3.311	0.000000082	Dsg2	−1.321	0.007420037	Kcna2 *	−1.135	0.000010021
DCP_1_1	−3.305	0.000000104	Ctxn3 *	−1.320	0.000571004	Pdcd7	−1.130	0.000002722
DCP_1_2	−3.265	0.000000074	44811	−1.312	0.000026796	Rfk *	−1.130	0.000006086
(+)E1A_r60_n9	−3.226	0.000000046	Tsc22d3	−1.310	0.000000244	DCP_22_0	−1.129	0.000012495
DCP_1_4	−3.021	0.000000100	Ppp1r17 *	−1.308	0.002923115	Hopx *	−1.129	0.000026010
(+)E1A_r60_n11	−2.947	0.000000148	Mdfic *	−1.305	0.004472728	Luc7l3 *	−1.126	0.000026473
DCP_1_7	−2.590	0.000008919	LOC100912629	−1.288	0.000747769	LOC102550744	−1.119	0.005486318
(+)E1A_r60_a97	−2.544	0.000000237	DCP_20_0	−1.282	0.000005016	A_44_P1360260	−1.109	0.000154546
Tmem72 *	−2.510	0.007744057	LOC102550328	−1.271	0.004325523	Tspan8 *	−1.105	0.001724714
Sulf1	−2.229	0.000483226	DCP_20_1	−1.250	0.000005873	Gpr153 *	−1.102	0.000028060
LOC102552325	−2.227	0.000000031	A_42_P629650	−1.241	0.006149048	Phf10 *	−1.100	0.000000022
LOC100363289	−2.177	0.000000006	Ppp1cb *	−1.237	0.001322118	Ptger3	−1.100	0.000486050
Lilrb3	−1.927	0.005040186	A_44_P1152848	−1.235	0.000018732	Zbtb44 *	−1.096	0.000000559
Sulf1 *	−1.712	0.000410239	Gpr88	−1.222	0.009585972	Pdgfa *	−1.090	0.000037189
A_44_P294461	−1.658	0.000223440	Tmem255a	−1.218	0.000643838	Pdcd7	−1.087	0.000000549
Myo5c *	−1.648	0.003145760	Mybl1 *	−1.217	0.000016766	LOC100912787	−1.087	0.000031819
Crb3 *	−1.624	0.000490731	Rai14 *	−1.211	0.000130225	Ly6d *	−1.086	0.002861825
Olr289	−1.604	0.005245154	Ptgfrn *	−1.206	0.000363580	Ppat *	−1.084	0.000006743
A_44_P860459	−1.542	0.000007407	LOC500034	−1.199	0.000110979	A_44_P177106	−1.081	0.000004555
LOC102552576	−1.536	0.000752949	RGD1565959	−1.199	0.000000527	Ets1 *	−1.077	0.000001179
A_44_P593525	−1.522	0.004426200	LOC316717	−1.192	0.000078774	A_44_P985758	−1.076	0.000113957
Klf5 *	−1.503	0.005835992	RGD1306148	−1.192	0.000076069	Tcerg1 *	−1.073	0.000202791
LOC103691368	−1.479	0.000082988	LOC103692770	−1.187	0.002610191	B4galt6	−1.071	0.000018871
A_44_P388174	−1.470	0.000000001	Zfp280d	−1.185	0.000039300	A_44_P176677	−1.071	0.000000307
Fam46a *	−1.399	0.000765256	Tmem196 *	−1.182	0.006645372	Slco1a2 *	−1.070	0.000040019
LOC102554942	−1.352	0.003180251	(+)E1A_r60_a20	−1.182	0.000004126	Hif1a *	−1.065	0.000178961
A_43_P21150	−1.346	0.000000263	Slc7a8 *	−1.181	0.000058397	Ccdc141 *	−1.063	0.000373571
Fubp1	−1.345	0.000005384	Fam160a1 *	−1.174	0.004680928	Slc5a9 *	−1.063	0.006396024
LOC102553223	−1.337	0.000009035	Tc2n *	−1.157	0.007031053	Klhl1 *	−1.062	0.002839968
Baiap2l1 *	−1.336	0.009749783	A_44_P648481	−1.148	0.000000677	Cgn	−1.057	0.002283754
Trappc2 *	−1.056	0.000660035	Cacng8 *	1.018	0.000075115	Rbbp4 *	1.076	0.000128378
Hemgn *	−1.049	0.000196549	Il24	1.020	0.000011484	A_64_P114084	1.077	0.000197679
A_44_P1158527	−1.048	0.003510234	Anp32a	1.021	0.000077440	Atn1	1.080	0.000001001
Cdh16 *	−1.048	0.005332964	A_44_P556745	1.022	0.000011711	A_64_P056703	1.081	0.000002902
Ptprv	−1.046	0.002163285	A_44_P1364899	1.022	0.000002641	Ak5 *	1.081	0.000000033
Hif1a	−1.044	0.000003090	Pcbp1	1.028	0.000002114	Gria1	1.087	0.000373241
Vom2r46	−1.042	0.004727577	LOC102552929	1.029	0.000185514	Cpa5 *	1.088	0.002460269
Dhx15 *	−1.041	0.000011149	A_44_P837263	1.033	0.000551838	Olr604	1.088	0.003650564
A_44_P704874	−1.037	0.000001503	Mgll *	1.035	0.000789768	A_64_P009178	1.090	0.000000761
A_42_P482051	−1.036	0.000000026	A_44_P330035	1.035	0.000001123	Grin2d *	1.091	0.000054051
Cdkn2d	−1.035	0.000180410	Arsg *	1.035	0.000001884	LOC102548371	1.091	0.000096129
A_44_P1155718	−1.031	0.000106181	A_44_P194939	1.036	0.000214844	Gapdh-ps1	1.091	0.000037813
A_44_P134496	−1.030	0.000002990	Mapre3 *	1.036	0.000002619	A_44_P503167	1.091	0.000487110
Vom1r35	−1.029	0.007863541	Slc8a2	1.037	0.000233388	A_44_P505440	1.092	0.000128723
Slc8a1	−1.026	0.000918729	Extl3 *	1.037	0.000062130	A_43_P10384	1.094	0.000000387
Mospd1	−1.024	0.004438125	Atp6v0c	1.038	0.000004797	A_43_P10121	1.103	0.000084547
LOC685680	−1.021	0.000126169	Rab3a	1.041	0.000029108	Prkcg *	1.108	0.000386664
A_43_P19304	−1.017	0.000007029	Csrp1 *	1.045	0.002809659	Galnt10 *	1.109	0.002419290
(+)E1A_r60_a22	−1.011	0.000015539	Limd2 *	1.046	0.000541715	LOC103694359	1.111	0.000211324
A_44_P261663	−1.008	0.000713982	Unc5a	1.047	0.000024450	LOC102555479	1.111	0.000012816
Tmem196	−1.003	0.007893654	Syngr1	1.059	0.000000505	A_44_P1153530	1.116	0.000619762
A_44_P239345	1.001	0.001658717	Hmx1 *	1.060	0.000030047	Gnas *	1.121	0.000025843
Kif1b *	1.002	0.000001844	LOC102554855	1.062	0.007443989	Cfap43	1.123	0.000000186
A_44_P122429	1.006	0.000002587	Ptprn2	1.064	0.000000228	Nacc1 *	1.125	0.000000057
A_44_P1159153	1.007	0.000000539	Glra2 *	1.068	0.000001483	A_44_P1156801	1.125	0.000010486
Zfp958	1.009	0.001508251	A_44_P944361	1.068	0.000001016	Cers1	1.133	0.000000376
Foxo1 *	1.010	0.000000660	A_44_P1363214	1.069	0.004653488	A_44_P1367985	1.135	0.000544312
Cntfr	1.012	0.005736210	Fibcd1	1.071	0.000559195	A_64_P101983	1.137	0.000054496
Pde3a *	1.014	0.002322651	Dlx3	1.075	0.000054847	Camk2a *	1.139	0.000129963
A_44_P237564	1.016	0.000099113	LOC102554145	1.076	0.006526812	Bcl11b *	1.142	0.001301627
A_44_P1364435	1.017	0.000098959	A_64_P147586	1.076	0.000000145	Crebbp *	1.144	0.000088531
Atp1a3 *	1.146	0.000007877	Cym	1.222	0.000004822	A_44_P1152546	1.406	0.000029247
A_44_P1364694	1.147	0.000050872	Csrnp2 *	1.228	0.000623765	A_64_P017723	1.438	0.000005293
S1pr5 *	1.148	0.002539634	LOC102555044	1.233	0.000000432	Aes	1.440	0.000005510
Clmp *	1.149	0.001954947	LOC103691813	1.236	0.000007215	Zc2hc1b	1.503	0.000080619
A_44_P1361950	1.150	0.000000231	Slc24a5	1.237	0.000000053	Ccl22 *	1.509	0.000008980
Gng3	1.151	0.000038855	A_44_P1041449	1.237	0.000000015	LOC100911409	1.536	0.000035945
LOC100912383	1.158	0.000231119	Nfix	1.239	0.000003119	A_44_P355294	1.546	0.000000079
LOC102555855	1.160	0.000575882	Cfl1 *	1.249	0.000000004	Hes7 *	1.586	0.000108971
A_44_P221213	1.162	0.000000231	A_44_P912004	1.249	0.000147097	A_44_P1363943	1.590	0.000041950
Gria1 *	1.163	0.000006308	Atp6v0c	1.252	0.000000255	LOC102553671	1.597	0.000036389
Lrrn4 *	1.163	0.000000421	Gngt1	1.257	0.006322879	LOC103691795	1.604	0.000000668
LOC103690307	1.166	0.000098665	Znrf4 *	1.260	0.000344007	A_44_P462228	1.604	0.000000024
Rassf2 *	1.167	0.000010655	A_64_P158343	1.263	0.000005071	LOC103690864	1.635	0.000089378
LOC102549602	1.170	0.000082615	Ube2g2	1.272	0.000007383	A_44_P169952	1.719	0.000000079
Ube2d1 *	1.171	0.000001592	Nsmf *	1.278	0.000001033	Cnih2	1.729	0.000083115
A_44_P201693	1.176	0.000004500	Shisa4 *	1.282	0.005315913	A_44_P363937	1.764	0.000008941
Nptxr	1.177	0.000126721	A_44_P122061	1.293	0.000000294	LOC103692432	1.820	0.000000001
Atp2a1 *	1.179	0.003887588	A_64_P123155	1.301	0.000000005	Zdhhc18	1.826	0.000075049
LOC102553558	1.180	0.000007378	A_44_P527614	1.305	0.000704143	LOC103695206	1.835	0.000000007
Capn15 *	1.184	0.000932570	Scn1b *	1.307	0.001017811	LOC102551957	1.838	0.000000027
Nek8	1.188	0.000001862	Eno1 *	1.310	0.000000043	Rn45s	1.932	0.000000449
LOC102547434	1.195	0.000004377	Srpr	1.317	0.000000051	LOC102723236	1.957	0.000050680
Cotl1	1.199	0.003224862	Zfhx2	1.317	0.000000006	LOC103693243	1.974	0.000015859
RGD1561017	1.201	0.006186444	Phyhip *	1.327	0.000004801	Fam20a *	1.982	0.000000000
Thy1	1.207	0.000000501	A_44_P574530	1.338	0.000463834	Tph1 *	2.004	0.008882666
LOC103692246	1.210	0.003204180	Prss35 *	1.350	0.000030099	LOC682526	2.037	0.000000041
Neurod2 *	1.213	0.000189934	A_64_P125130	1.355	0.000020770	Rn5–8s	2.793	0.000016169
S100a7a	1.214	0.001279380	A_44_P413787	1.381	0.000000031	LOC310926	3.340	0.000179384
44809	1.218	0.000002062	Olfm1 *	1.394	0.000011652	Rn45s	3.402	0.000000079
LOC103690992	1.220	0.002043341	A_44_P1155460	1.394	0.000069586	Rn18s	3.834	0.000000018
LOC680959	1.222	0.000114768	A_64_P088257	1.399	0.000000002	Rn45s	4.844	0.000000038

In instances where gene name was not available, gene ID was provided. Asterisk indicates genes containing an androgen response element (ARE). Bold indicates genes known from the literature to be androgen responsive.

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Table 1 Effects of androgen deprivation on gene expression in dorsal hippocampus.

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