Fig. 2: Differentially expressed genes (DEGs) (FDR < 0.05 and |log₂FC| > 0.5) between the phenotypes at different time points in the SCN.

A Number of DEGs at pooled time points. At the global comparison level, there were 16, 5 and 7 DEGs in resilient-to-control, susceptible-to-control and resilient-to-susceptible comparisons, respectively. Daytime comparison revealed 2, 3 and 1 DEGs for resilient-to-control, susceptible-to-control and susceptible-to-resilient comparisons, respectively. Nighttime comparison revealed 338, 11 and 10 DEGs for resilient-to-control, susceptible-to-control and susceptible-to-resilient comparisons, respectively. B Number of DEGs at specific time points. At ZT4, there were 0, 3 and 7 DEGs for resilient-to-control, susceptible-to-control and resilient-to-susceptible comparisons. At ZT10, there were no DEGs for any phenotypic comparison. At ZT16, there were 758, 17 and 23 DEGs for resilient-to-control, susceptible-to-control and resilient-to-susceptible comparisons, respectively. At ZT22, there were 0, 0 and 34 DEGs for resilient-to-control, susceptible-to-control and resilient-to-susceptible, respectively. C Nighttime comparison: Volcano plot showing significant DEGs (FDR < 0.05) in resilient mice relative to controls at nighttime comparison level in SCN. D ZT16 comparison: Volcano plot showing significant DEGs (FDR < 0.05) in resilient mice relative to controls at ZT16 in SCN. Red and blue points represent significantly upregulated and downregulated genes, respectively.