Fig. 4: The mediating effect of orexin A level in CSF on the association between the grey matter volume of the right dorsal medial thalamic nucleus and depression. | Translational Psychiatry

Fig. 4: The mediating effect of orexin A level in CSF on the association between the grey matter volume of the right dorsal medial thalamic nucleus and depression.

From: Alzheimer’s disease with depression: clinical characteristics and potential mechanisms involving orexin and brain atrophy

Fig. 4: The mediating effect of orexin A level in CSF on the association between the grey matter volume of the right dorsal medial thalamic nucleus and depression.

The correlation between orexin A level in CSF and the grey matter volume of right dorsal medial thalamic nucleus in AD patients was analyzed. r = −0.443 [P < 0.001, 95%CI (−0.639, -0.199)] (A). Mediation model assessing whether orexin A level in CSF (M) mediated the relationship between the grey matter volume of right dorsal medial thalamic nucleus (X exposure) and depressive symptoms (Y outcome) (B). Path a: the effect of one-unit change in exposure on mediator; Path b: effect of one-unit change in mediator on outcome adjusted for exposure; Path c′(direct effect): the effect of one-unit change in exposure on outcome independent of mediator value. r = - 15.453 [P < 0.001, 95%CI (−28.84, −4.22)]. a * b (indirect effect): the effect of one-unit change in exposure on the outcome through mediator change. r = −14.617 [P < 0.001, 95%CI (−25.31, −2.18)]. Standardized estimates were provided. The proportion of mediation is the percentage of the mediated variables that explain the correlation between X and Y. Proportion of mediation = 49.2%. CI confidence intervals, CSF cerebrospinal fluid, HAMD Hamilton Depression.

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