Table 1 MR testing the causality from NT1 to schizophrenia using non-HLA NT1 lead variants and including one lead variant in LD with HLA-DQB1*06:02 in European ancestry cohort.
From: Narcolepsy as a potential risk factor for Schizophrenia
Method | Exposure | No. of SNPs | Beta | SE | P-Val | OR [95% CI] |
|---|---|---|---|---|---|---|
MR Egger | HLA-independent | 13 | 0.023 | 0.042 | 0.59 | 1.024 [0.941–1.113] |
+1 HLA variant | 14 | 0.042 | 0.015 | 0.029 | 1.043 [1.011–1.076] | |
Weighted median | HLA-independent | 13 | 0.059 | 0.022 | 0.007 | 1.061 [0.016–1.107] |
+1 HLA variant | 14 | 0.048 | 0.012 | 6.87E-05 | 1.049 [1.023–1.076] | |
Inverse variance weighted | HLA-independent | 13 | 0.058 | 0.017 | 6.0E-4 | 1.06 [1.024–1.096] |
+1 HLA variant | 14 | 0.052 | 0.01 | 4.48E-07 | 1.054 [1.032–1.076] | |
Simple mode | HLA-independent | 13 | 0.097 | 0.044 | 0.048 | 1.101 [1.01–1.201] |
+1 HLA variant | 14 | 0.09 | 0.032 | 0.015 | 1.094 [1.028–1.164] | |
Weighted mode | HLA-independent | 13 | 0.053 | 0.026 | 0.062 | 1.05 [1.002–1.11] |
+1 HLA variant | 14 | 0.049 | 0.011 | 8.007E-04 | 1.05 [1.025–1.076] |
