Table 2 MR results testing the causality between schizophrenia and NT1 in FinnGen R12 and NT1 meta-analysis.
From: Narcolepsy as a potential risk factor for Schizophrenia
Method | Outcome | No. of SNPs | Beta | SE | P-Val | OR [95% CI] |
|---|---|---|---|---|---|---|
MR Egger | FinnGen R12 narcolepsy cohort | 578 | 0.436 | 0.286 | 0.128 | 1.546 [0.882–2.710] |
NT1 meta-analysis | 558 | 0.0437 | 0.096 | 0.648 | 1.044 [0.865–1.261] | |
Weighted median | FinnGen R12 narcolepsy cohort | 578 | 0.093 | 0.120 | 0.437 | 1.098 [0.867–1.390] |
NT1 meta-analysis | 558 | 0.080 | 0.036 | 0.025 | 1.083 [1.009–1.162] | |
Inverse variance weighted | FinnGen R12 narcolepsy cohort | 578 | 0.124 | 0.081 | 0.125 | 1.133 [0.965–1.329] |
NT1 meta-analysis | 558 | 0.060 | 0.025 | 0.015 | 1.062 [1.011–1.116] | |
Simple mode | FinnGen R12 narcolepsycohort | 578 | −0.423 | 0.482 | 0.380 | 0.654 [0.254–1.685] |
NT1 meta-analysis | 558 | 0.196 | 0.151 | 0.196 | 1.216 [0.903–1.639] | |
Weighted mode | FinnGen R12 narcolepsy cohort | 578 | −0.124 | 0.452 | 0.783 | 0.883 [0.363–2.144] |
NT1 meta-analysis | 558 | 0.223 | 0.143 | 0.119 | 1.251 [0.944–1.657] |
