Fig. 1: Polygenic overlap between SCZ and AD.
From: Identification of genetic architecture shared between schizophrenia and Alzheimer’s disease
Conditional Q-Q figures of nominal versus empirical -log10 P values in AD below the conventional GWAS significant threshold of P < 5 × 10−8 with SCZ A and vice versa B, at different levels of significance P ≤ 1, P ≤ 0.1, P ≤ 0.01, P ≤ 0.001, P ≤ 0.0001, separately, are shown. The purple lines indicate all SNPs. The gray lines indicate the null hypothesis. Increasing leftward deflection from the gray line for SNPs with higher significance in the conditional phenotype indicates polygenic overlap. AD Alzheimer’s disease, SCZ schizophrenia.
