Fig. 2: Correlations between TCA cycle-related metabolites and clinical symptoms or cognitive performance in BD.

Correlations with clinical symptoms: a Isocitric acid levels were negatively correlated with HAMA score. b α-KG, c succinic acid, d fumaric acid, e lactate and (f) pyruvate were positively associated with HAMA score. Correlations with cognitive performance: g oxaloacetic acid and (i) α-KG were negatively correlated with picture naming, while (h) citric acid was negatively correlated with list learning.