Fig. 1: Intergroup differences in CSF C1q among different AD pathology classification. | Translational Psychiatry

Fig. 1: Intergroup differences in CSF C1q among different AD pathology classification.

From: Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer’s disease

Fig. 1

Notes: Levels of Transformed CSF C1q were significantly lower in A+ (A), T- (B), N- (C), and lowest in 1 group (D). CSF C1q levels fitted the normal distribution after log10 transformation and then standardized by z-scale. P values were computed with the One-way ANCOVA for comparison of means while Fisher’s LSD was employed for post hoc test. Models included age, gender, education, APOE ε4 status. Significant effects: *P < 0.05; **P < 0.01; ***P < 0.001. Abbreviations: CSF cerebrospinal fluid, C1q Complement 1q: B_VPGLYYFTYHASSR, AD Alzheimer Disease, APOE apolipoprotein E, A amyloidosis, T tau pathology, N neurodegeneration, 0/1/2 stage 0/1/2, SNAP Suspected Non-AD Pathology.

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