Fig. 2: Associations between CSF C1q and AD biomarkers. | Translational Psychiatry

Fig. 2: Associations between CSF C1q and AD biomarkers.

From: Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer’s disease

Fig. 2

Levels of CSF C1q were positively associated with CSF sTREM2 (A), GFAP (B), Aβ42 (C), as well as higher levels of CSF P-tau (D) and T-tau (E). Measures were fitted the normal distribution after log10 transformation and then standardized by z-scale. Multiple linear regression was adjusted for age, gender, educational level, and APOE ε4 carrier status. Significant effects (P < 0.05) are shown in bold. Abbreviations: CSF cerebrospinal fluid, C1q Complement 1q: B_VPGLYYFTYHASSR, ADAS Alzheimer Disease Assessment Scale, APOE apolipoprotein E, Aβ42 Amyloid-42, P-tau phosphorylated-tau, T-tau total-tau, sTREM2 soluble triggering receptor expressed on myeloid cells 2, GFAP glial fibrillary acidic protein.

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