Fig. 2: Model GC electrophysiology for HC, LR and NR models, with and without lithium. | Translational Psychiatry

Fig. 2: Model GC electrophysiology for HC, LR and NR models, with and without lithium.

From: The effects of bipolar disorder granule cell hyperexcitability and lithium therapy on pattern separation in a computational model of the dentate gyrus

Fig. 2: Model GC electrophysiology for HC, LR and NR models, with and without lithium.

A frequency-current relationships. BD models are more excitable than HC models, and excitability is reduced for LRs and HCs after lithium exposure (dashed lines). B Sodium current-voltage relationships. Lithium reduces sodium current magnitudes for LRs and HCs. C Potassium current-voltage relationships. NRs have greater potassium currents than LRs and HCs.

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