Fig. 3: Effects of BD models on pattern separation (PS). | Translational Psychiatry

Fig. 3: Effects of BD models on pattern separation (PS).

From: The effects of bipolar disorder granule cell hyperexcitability and lithium therapy on pattern separation in a computational model of the dentate gyrus

Fig. 3: Effects of BD models on pattern separation (PS).

A Healthy levels of spontaneous activity (SA) used for HC and NR models (0.1 Hz [25]), and B pathological levels of spontaneous activity used for the LR condition (Healthy = 0.1 Hz; BD = 1 Hz, normalised to healthy levels after lithium exposure [25]). Error bars show standard error of the mean, for 14 simulation runs initialised with different random seeds to incorporate variability in network connectivity and granule cells selected for spontaneous activation.

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