Fig. 4: Effects of lithium on healthy control winner-take-all dynamics in DG model, and cellular response to negative currents both in silico and in vitro. | Translational Psychiatry

Fig. 4: Effects of lithium on healthy control winner-take-all dynamics in DG model, and cellular response to negative currents both in silico and in vitro.

From: The effects of bipolar disorder granule cell hyperexcitability and lithium therapy on pattern separation in a computational model of the dentate gyrus

Fig. 4: Effects of lithium on healthy control winner-take-all dynamics in DG model, and cellular response to negative currents both in silico and in vitro.

Winner-take-all dynamics in DG model are shown in panels A, B, and cellular response to negative currents in GC model and in-vitro are shown in panels C, D respectively. A GC activity after direct spontaneous stimulation (SS) (“-AC”), and B activity of remaining GCs not directly stimulated by spontaneous activity (“-RM”) in lamella 3 only. C HC-CTRL and HC-LITM GC computational model behaviour in response to negative current injection, and D HC-CTRL and HC-LITM iPSC GC in-vitro behaviour in response to negative current injection. Error bars show standard error of the mean.

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