Table 1 Neurodevelopmental and Neurodegenerative diseases and their associated brain cell types.
From: Mapping human brain cell type origin and diseases through single-cell transcriptomics
Disorders | Key altered cell types | Description | Article type | PMID |
|---|---|---|---|---|
Alzheimer’s Disease | Microglia, astrocytes, neurons | Single-cell RNA-seq neuroinflammation | Analysis | 36090352 |
Microglia, astrocytes, neurons | scRNA-seq of AD brain inflammation | Analysis | 36090352 | |
Microglia, astrocytes | Single-cell RNA + ATAC in AD | Analysis | 38345145 | |
Autism Spectrum Disorder | Serotonergic neurons, GABAergic interneurons, cerebellar neurons | Rodent genetic models in ASD | Review | 24290383 |
Excitatory neurons (upper-layer), microglia | snRNA-seq of postmortem ASD brains | Analysis | 31097668 | |
Microglia, astrocytes, oligodendrocytes, neurons | Multi-omic single-cell transcriptomics in ASD | Analysis | 36945369 | |
Multiple neurons and glia | Genetics to neurobiology of ASD | Review | 25464374 | |
Neurons, microglia | Transcriptomic and epigenetic profiling | Analysis | 36323788 | |
Various brain cell types | Computational modeling of ASD genetics | Analysis | 33519924 | |
Cortical neurons, microglia | Single-cell genomics of ASD | Analysis | 33214565 | |
Excitatory and inhibitory neurons | Single-cell transcriptomics in ASD | Analysis | 35739273 | |
Neurons, microglia, astrocytes | Multi-modal single-cell RNA + ATAC sequencing | Analysis | 38699615 | |
Neurons and glia | Genetics and molecular pathways in ASD | Review | 25464374 | |
Neurons, microglia | Transcriptomic profiling in ASD | Analysis | 34802461 | |
Multiple brain cell types | Single-cell multi-omics in ASD | Analysis | 38419654 | |
Cortical neurons, microglia | Single-cell genomics in ASD | Analysis | 33214565 | |
Excitatory and inhibitory neurons | Single-cell transcriptomics in ASD | Analysis | 35739273 | |
Neurons, microglia, astrocytes | Multi-modal single-cell RNA + ATAC sequencing | Analysis | 38699615 | |
Excitatory neurons, microglia | Transcriptomic profiling in ASD | Analysis | 32439845 | |
Neurons, microglia | Transcriptomic profiling in ASD cortex | Analysis | 34802461 | |
Multiple brain cell types | Multi-modal single-cell multi-omics in ASD | Analysis | 38419654 | |
Neurons, microglia, astrocytes | Multi-modal scRNA + ATAC sequencing | Analysis | 38699615 | |
Cortical neurons, microglia | Single-cell genomics in ASD | Analysis | 33214565 | |
Excitatory and inhibitory neurons | Single-cell transcriptomics in ASD | Analysis | 35739273 | |
Excitatory neurons, microglia | Transcriptomic profiling in ASD | Analysis | 32439845 | |
Neurons, microglia | Multi-omics single-cell RNA + epigenomics | Analysis | 38391931 | |
Cortical excitatory neurons | Single-cell RNA-seq in ASD | Analysis | 27940202 | |
Microglia, neurons | Single-cell transcriptomics in ASD | Analysis | 35338313 | |
Microglia, astrocytes | snRNA-seq and multi-omics in ASD | Analysis | 34888832 | |
Excitatory neurons, microglia, astrocytes, oligodendrocytes, interneurons | Single-cell RNA-seq enrichment ASD genes | Analysis | 26858593 | |
Excitatory neurons, microglia, astrocytes, oligodendrocytes, interneurons | Single-cell RNA-seq study on mouse/human brain, ASD gene enrichment | Analysis | 26858593 | |
Bipolar Disorder | Excitatory neurons, inhibitory neurons | snRNA-seq study of human cortex | Analysis | 31031006 |
Excitatory neurons, inhibitory neurons | snRNA-seq of human cortex | Analysis | 31031006 | |
Schizophrenia | Cortical interneurons, excitatory neurons | Postmortem snRNA-seq of schizophrenia | Analysis | 30550949 |
Cortical interneurons, excitatory neurons | Postmortem snRNA-seq in schizophrenia | Analysis | 30550949 | |
Cortical neurons, interneurons | snRNA-seq in schizophrenia | Analysis | 37321420 | |
Excitatory neurons, interneurons | snRNA-seq data on schizophrenia | Analysis | 37121366 | |
Cortical neurons, interneurons | Single-nucleus RNA-seq in schizophrenia | Analysis | 29785013 | |
Huntington’s Disease | Medium spiny neurons | Transcriptomic profiling of Huntington’s | Analysis | 28522972 |
Medium spiny neurons, microglia | Single-cell transcriptomics uncover early glial and neuronal alterations in HD progression. | Analysis | 33593693 | |
Striatal neurons, microglia | Epigenetic and transcriptomic analysis identifies gene expression changes in HD brains. | Analysis | 31316211 | |
Medium spiny neurons | Single-nucleus RNA-seq reveals selective vulnerability of neuronal subtypes in HD. | Analysis | 32736085 | |
Parkinson’s Disease | Dopaminergic neurons, microglia | Multi-omics snRNA-seq in Parkinson’s | Analysis | 37773446 |
Dopaminergic neurons, astrocytes, microglia | Review discussing PD pathogenesis including roles of glial cells and neuron-glia interactions. | Review | 31437219 | |
Dopaminergic neurons, oligodendrocytes | Single-nucleus RNA-seq identifies transcriptional alterations in specific brain cell types in PD. | Analysis | 33188239 | |
Dopaminergic neurons, microglia | Transcriptomic profiling of midbrain neurons reveals selective vulnerability in PD. | Analysis | 32053786 | |
Dopaminergic neurons, astrocytes, microglia | Neuroinflammation-focused review highlighting astrocyte and microglia contributions to PD. | Review | 34072062 |
