Table 2 Regions of significant differences in fractional anisotropy between individuals with suicidal thoughts and behaviours (STBs) relative to controls.
From: Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis
Cluster | Tract Involvement | |||||||
|---|---|---|---|---|---|---|---|---|
Cluster (Size) | MNIa Coordinates | SDMb value | p value | I2 | Egger test | Associated Tracts | Overlap Score (%)c | Disconnection Score (%)d |
STBs < Controls | ||||||||
Cluster 1 Right Fronto-Temporo-Occipital (192 voxels) | 38, -2, -24 | -2.071 | <0.001 | 0% | t12 = 2.38, p = 0.035 (but direction opposite to small-study effects) | Right uncinate fasciculus | 4.99 | 90.81 |
Right inferior longitudinal fasciculus | 0.92 | 38.45 | ||||||
Right inferior fronto-occipital fasciculus | 1.44 | 37.96 | ||||||
Fornix | 2.18 | 18.13 | ||||||
Cluster 2 Left Fronto-Temporo-Occipital (99 voxels) | -32, 2, -12 | -1.583 | <0.001 | 8% | t12 = 1.65, p = 0.125 | Left uncinate fasciculus | 1.98 | 58.81 |
Left inferior fronto-occipital fasciculus | 0.55 | 37.28 | ||||||
Fornix | 0.82 | 8.30 | ||||||
Left inferior longitudinal fasciculus | 0.44 | 3.28 | ||||||
Cluster 3 Corpus Callosum and Cingulum (74 voxels) | 6, 16, 18 | -1.590 | <0.001 | 0% | t12 = 1.87, p = 0.086 | Corpus callosum (anterior) | 0.85 | 30.30 |
Corpus callosum (rostral body) | 0.64 | 18.76 | ||||||
Corpus callosum (posterior body) | 0.21 | 7.85 | ||||||
Right cingulum | 0.10 | 7.16 | ||||||
STBs > Controls | ||||||||
No significant clusters | ||||||||
