Fig. 5: Inhibition of vHPC to NAc glutamatergic projection neurons disrupts reconsolidation of cocaine contextual memories. | Translational Psychiatry

Fig. 5: Inhibition of vHPC to NAc glutamatergic projection neurons disrupts reconsolidation of cocaine contextual memories.

From: The ventral hippocampus and nucleus accumbens as neural substrates for cocaine contextual memory reconsolidation

Fig. 5: Inhibition of vHPC to NAc glutamatergic projection neurons disrupts reconsolidation of cocaine contextual memories.

AAVretro-hSyn-DIO-hM4D(Gi)-mCherry or control AAVretro-hSyn-mCherry vector was injected bilaterally into the nucleus accumbens and AAV-CamKII-Cre into the vHPC of mice, to express iDREADDs specifically in the vHPC→NAc pathway. A Mice expressing vHPC to NAc iDREADDs or vector controls show similar cocaine CPP on Day 9. On Day 10, mice were re-exposed to the cocaine context and injected with CNO (5 mg/kg) or vehicle. CPP was retested on Day 13. CPP scores on Day 13 were significantly lower in mice expressing iDREADDs and injected with CNO compared to both vehicle and vector control mice (*p < 0.05; ***p < 0.001). Day 13 scores were also significantly lower for the iDREADD + CNO group on Day 13 versus Day 9 (**** p < 0.0001). B Representative image of expression of mCherry in the NAc (left) and in the vHPC (right).

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