Table 3 Results of the analysis of psychiatric disorders on inflammatory proteins.

From: Circulating inflammatory proteins associated with risks of schizophrenia, bipolar disorder, and major depressive disorder: a mendelian randomization study

Exposures

Outcomes

IVs (N)

Method

OR (95% CI)

P value

SCZ

IL20RA

330

MR-IVW

0.97 (0.94, 1.00)

0.021

Weighted median

0.95 (0.91, 0.99)

0.024

MR Egger

0.98 (0.89, 1.08)

0.691

Simple mode

0.88 (0.76, 1.02)

0.086

Weighted mode

0.92 (0.81, 1.03)

0.155

SCZ

NTF3

351

MR-IVW

1.03 (1.00, 1.05)

0.035

Weighted median

1.02 (0.99, 1.06)

0.198

MR Egger

1.01 (0.93, 1.10)

0.823

Simple mode

1.04 (0.91, 1.19)

0.558

Weighted mode

1.02 (0.92, 1.14)

0.669

MDD

CCL19

209

MR-IVW

1.11 (1.03, 1.20)

0.008

Weighted median

1.07 (0.96, 1.20)

0.212

MR Egger

1.04 (0.76, 1.41)

0.823

Simple mode

1.01 (0.73, 1.39)

0.967

Weighted mode

1.04 (0.77, 1.41)

0.779

MDD

FGF19

209

MR-IVW

0.93 (0.86, 1.00)

0.043

Weighted median

0.85 (0.77, 0.94)

0.002

MR Egger

0.77 (0.58, 1.04)

0.094

Simple mode

0.80 (0.58, 1.10)

0.177

Weighted mode

0.79 (0.57, 1.09)

0.151

MDD

SCF

208

MR-IVW

1.09 (1.01, 1.17)

0.033

Weighted median

1.09 (0.98, 1.21)

0.101

MR Egger

0.91 (0.68, 1.23)

0.551

Simple mode

1.25 (0.88, 1.76)

0.209

Weighted mode

1.20 (0.88, 1.62)

0.248

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