Fig. 2: Differential genes in the hippocampus between the control group and isotretinoin-treated group. | Translational Psychiatry

Fig. 2: Differential genes in the hippocampus between the control group and isotretinoin-treated group.

From: Chronic administration of isotretinoin induces depressive- and anxiety-like behaviors by altering the neuroactive ligand-receptor interaction pathway in adolescent mice

Fig. 2

A 203 differential genes (n = 96, up-regulated; n = 107, down-regulated) between the two groups were identified. B The results of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation showed that signaling molecules and interaction (KEGG level 2) had the most differential genes. C The results of KEGG enrichment analysis showed that there were six changed pathways (KEGG level 3), and neuroactive ligand-receptor interaction under the signaling molecules and interaction category had six differential genes. D Melanocortin 3 receptor (MC3R), cholinergic receptor nicotinic beta 4 subunit (Chrnb4), pyroglutamylated RFamide peptide receptor like (Qrfprl), pro-opiomelanocortin (Pomc) and growth hormone (Gh) were significantly decreased in the isotretinoin-treated group, and Trhr2 was significantly increased in the isotretinoin-treated group.

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