Fig. 6: Correlations between differential metabolites and behavioral phenotypes. | Translational Psychiatry

Fig. 6: Correlations between differential metabolites and behavioral phenotypes.

From: Chronic administration of isotretinoin induces depressive- and anxiety-like behaviors by altering the neuroactive ligand-receptor interaction pathway in adolescent mice

Fig. 6

A The percentage of sucrose preference (SP%) had significant relationships with six differential metabolites under the neuroactive ligand-receptor interaction pathway. B Taurine in the prefrontal cortex had close relationships with the other five differential metabolites (Adenosine, Tyramine, N-Acetylaspartylglutamic Acid, Adenosine Diphosphate (ADP) in the prefrontal cortex; and Taurine in serum) significantly related to SP% and was also significantly related to histamine in serum. C The relative abundance of taurine in MDD patients (n = 56) compared to healthy controls (n = 35). D The relative abundance of taurine in MDD-suicide attempters (n = 21), MDD-non attempters (n = 35), and healthy controls (n = 35). Data are presented as mean ± SEM.

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