Fig. 7: Impact of eFT508 treatment on Aβo-induced changes in de novo protein synthesis. | Translational Psychiatry

Fig. 7: Impact of eFT508 treatment on Aβo-induced changes in de novo protein synthesis.

From: Low concentrations of amyloid-beta oligomers induce synaptogenesis characteristic for mild cognitive impairment and alter the de novo proteome

Fig. 7: Impact of eFT508 treatment on Aβo-induced changes in de novo protein synthesis.

Aβo induced primarily changes in de novo protein synthesis regarding the synapse, cytoskeleton, mitochondria, autophagy, and UPS. Many of these changes were prevented or reduced by eFT508 treatment, as indicated by the loss of significance when comparing control vs Aβo + eFT508. For simplicity the error bars are not indicated. n = 5-6 per group, * = significantly different in a t-test comparison, ns = not significant.

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