Table 2 Polygenic scores (PGS) associated with stimulant discontinuation in individuals with ADHD.

From: Common and rare variant contributions to discontinuation of stimulant treatment in ADHD

   

DISCALL

   

DISCbelow16

   

DISCabove16

 

PGS

OR

LCI

UCI

FDR_p

OR

LCI

UCI

FDR_p

OR

LCI

UCI

FDR_p

P-factor

1.11

1.08

1.14

6.96E-10

1.12

1.08

1.17

2.69E-07

1.08

1.03

1.14

0.0284

Schizophrenia

1.10

1.06

1.13

5.83E-08

1.10

1.05

1.14

7.24E-05

1.09

1.03

1.14

0.0253

Major depression

1.05

1.02

1.09

0.0073

1.06

1.02

1.11

0.0147

1.02

0.97

1.07

0.8814

Bipolar disorder

1.05

1.02

1.08

0.0085

1.05

1.01

1.09

0.0514

1.05

0.99

1.10

0.3404

Obsessive compulsive disorder

1.05

1.02

1.08

0.0189

1.08

1.04

1.13

0.0009

1.00

0.95

1.05

0.9493

IQ

0.96

0.93

0.99

0.0435

0.99

0.95

1.03

0.8164

0.91

0.87

0.96

0.0170

Educational attainment

1.00

0.97

1.04

0.8848

1.06

1.02

1.11

0.0137

0.93

0.88

0.97

0.0304

Body mass index

0.93

0.90

0.96

5.29E-05

0.90

0.86

0.94

2.68E-06

0.97

0.92

1.02

0.5368

Self-reported migraine

0.99

0.96

1.02

0.6601

0.94

0.91

0.98

0.0148

1.06

1.01

1.12

0.0887

Lifetime cannabis use

1.03

1.00

1.07

0.1314

1.06

1.02

1.10

0.0177

0.99

0.94

1.04

0.9239

  1. Odds ratios (OR) per PGS associated with discontinuation in at least one group, presented together with lower- and upper 97.5% confidence limits (LCI, UCI) and false discovery rate (FDR) corrected p-values (FDR_p) are shown for the full sample (DISCALL) including 18,362 (7102 discontinuers), for the 12,229 individuals (3,598 discontinuers) <16 years of age at first dispensation (DISCbelow16), and for the 6133 individuals (3504 discontinuers) ≥16 years of age at first dispensation (DISCabove16). Statistically significant effects are given in bold.
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