Fig. 3: Correlations Between White Matter Hyperintensities in Different Regions and Global Cognitive Function. | Translational Psychiatry

Fig. 3: Correlations Between White Matter Hyperintensities in Different Regions and Global Cognitive Function.

From: Stage-Dependent mediation of white matter hyperintensities between plasma biomarkers and cognitive function in Alzheimer’s disease

Fig. 3: Correlations Between White Matter Hyperintensities in Different Regions and Global Cognitive Function.

After adjusting for gender, age, and education level, lgjuxWMH, lgpWMH, and lgjcWMH volumes showed significant negative correlations with MMSE (r = −0.21, P < 0.001; r = −0.18, P = 0.002; r = −0.21, P < 0.001, respectively) (A–C) and MoCA scores (r = −0.32, P < 0.001; r = −0.25, P < 0.001; r = −0.19, P = 0.001, respectively) (D–F). Abbreviations: AD, Alzheimer’s disease; dWMH, deep white matter hyperintensities; HC, healthy controls; jcWMH, subcortical white matter hyperintensities; juxWMH, juxtaventricular white matter hyperintensities; MCI, mild cognitive impairment; pWMH, periventricular white matter hyperintensities; SCD, subjective cognitive decline; lg represents log10 transformation of white matter hyperintensities.

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