Table 2 Relationship Between Aβ42/Aβ40 Levels and Cognition.

From: Stage-Dependent mediation of white matter hyperintensities between plasma biomarkers and cognitive function in Alzheimer’s disease

 

Aβ42/40

Variables

Sample

β(95%CI)

P

Whole cohort

   

MMSE

294

0.207(44.682,135.479)

<0.001ab

MoCA

293

0.265(80.832,172.075)

<0.001ab

Executive

284

−0.152(−19.374,−2.980)

0.008ab

Memory

287

0.164(4.117,17.614)

0.002a

Language

293

0.276 (11.716,23.691)

<0.001ab

CU

   

MMSE

124

0.140(−6.276,55.922)

0.117

MoCA

124

0.268(80.832,172.075)

0.001ab

Executive

124

−0.100(−4.411,1.265)

0.275

Memory

124

0.132(−1.706,11.969)

0.140

Language

124

0.345 (7.115,19.249)

<0.001ab

CI

   

MMSE

170

0.219(39.596,190.682)

0.003ab

MoCA

169

0.274(72.693,216.457)

<0.001ab

Executive

160

−0.152(−29.594,0.200)

0.053

Memory

163

0.122(−1.552,18.089)

0.098

Language

169

0.217 (5.344,22.637)

0.001ab

  1. 95%CI, 95% confidence interval; CU, cognitively unimpaired; CI, cognitively impaired; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment.
  2. arepresents P < 0.05 after FDR correction.
  3. brepresents still significant after regressing out APOE 4 status.
  4. Bold P values indicate statistically significant differences.
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