Table 1 Demographic and clinical characteristics of the participants.

From: Brain functional network correlates and predictors of the perioperative antidepressant effect of esketamine in breast cancer patients: a double-blind randomized controlled trial using resting-state fMRI and graph theory

Characteristic

Esketamine group

(n = 18)

Placebo group

(n = 17)

HC

(n = 35)

Statistic

p value

Age (years), mean ± SD

49.89 ± 9.69

50.12 ± 9.04

50.00 ± 9.24

F = 0.003

0.997

Height (m), mean ± SD

1.61 ± 0.56

1.60 ± 0.34

 

t = 0.318

0.753

Weight (kg), mean ± SD

63.03 ± 7.53

61.53 ± 8.70

 

t = 0.546

0.589

BMI (kg/m2) a

24.45 ± 2.84

23.99 ± 3.23

 

t = 0.452

0.654

FD (baseline)

0.17 ± 0.13

0.11 ± 0.04

0.15 ± 0.08

F = 1.982

0.146

FD (follow-up)

0.13 ± 0.05

0.12 ± 0.05

 

t = 0.783

0.439

Preoperative comorbidities-no (%)

     

Hypertension

5 (27.78)

4 (23.53)

 

χ2 = 0.083

0.774

Diabetes mellitus

1 (5.56)

2 (11.26)

 

χ2 = 0.430

0.512

Coronary heart disease

0

1 (5.88)

 

χ2 = 1.090

0.296

Lung disease

1 (5.56)

0

 

χ2 = 0.972

0.324

Cerebrovascular disease

0

0

 

χ2 = 1.987

>0.999

Liver disease

0

2 (11.76)

 

χ2 = 2.246

0.134

Kidney disease

0

0

 

χ2 = 1.987

>0.999

Hematologic disease

0

0

 

χ2 = 1.987

>0.999

Disability

0

0

 

χ2 = 1.987

>0.999

Age-adjusted Charlson comorbidity index-no (%)

   

Z = −0.187

0.851

2

4 (22.22)

2 (11.76)

   

3

2 (11.11)

5 (28.41)

   

4

6 (33.33)

6 (35.30)

   

5

5 (27.78)

2 (11.76)

   

≥6

1 (5.56)

2 (11.76)

   

ASA physical status-no (%)

   

Z = −0.866

0.386

Ⅱ

9 (50)

11 (64.70)

   

Ⅲ

9 (50)

6 (35.30)

   

Chronic smoking-no (%)

0

0

 

χ2 = 1.987

>0.999

Alcoholism-no (%)

0

1 (5.88)

 

χ2 = 1.090

0.296

Education level (yr)-no (%)

   

Z = −0.997

0.319

<2

3 (16.67)

3 (17.65)

   

2–5

13 (72.22)

14 (82.35)

   

>5

2 (11.11)

0

   

Marriage status-no (%)

   

χ2 = 0.972

0.324

Unmarried

0

0

   

Married

17 (94.44)

17 (100)

   

Divorced/widowed

1 (5.56)

0

   

Employment status-no (%)

   

χ2 = 2.967

0.227

Employed

7 (38.89)

9 (52.94)

   

Retired

5 (27.78)

1 (5.88)

   

Unemployed

6 (33.33)

7 (41.18)

   

Menopause-no (%)

13 (72.22)

8 (47.06)

 

χ2 = 2.307

0.129

SSRS score, mean ± SDb

33.94 ± 7.72

35.73 ± 5.22

 

t = −0.763

0.451

MADRS score, mean ± SDc

19.39 ± 3.38

19.06 ± 3.82

 

t = 0.271

0.788

PHQ-9 score, mean ± SDd

10.28 ± 2.24

9.82 ± 2.58

 

t = 0.557

0.581

GAD-7 score, mean ± SDe

7.22 ± 2.18

6.41 ± 2.70

 

t = 0.980

0.334

PSQI score, mean ± SDf

5.11 ± 2.03

5.12 ± 3.57

 

t = −0.007

0.995

  1. HC, healthy controls; FD, frame-wise displacement; SD, standard deviation; no, number.
  2. a Body mass index (BMI) is the weight in kilograms divided by the square of the height in meters.
  3. b Scores on the Social Support Rating Scale (SSRS) range from 11 to 62, with higher scores indicating better social support.
  4. c Scores on the Montgomery–Åsberg Depression Rating Scale (MADRS) range from 0 to 60, with higher scores indicating more severe depression.
  5. d Scores on the 9-item Patient Health Questionnaire (PHQ-9) scale range from 0 to 27, with higher scores indicating a greater frequency of symptoms.
  6. e Scores on the Generalized Anxiety Disorder scale (GAD-7) scale range from 0 to 21, with higher scores indicating more severe anxiety.
  7. f Scores on the Pittsburgh sleep quality index (PSQI) scale range from 0 to 21, with higher scores being associated with poorer sleep quality.
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